Opioid and fentanyl vaccine patents A dive into the opioid crisis
Chemical warfare all the way around getting hit from all sides
Opioid deaths rose during the covid-19 lock downs Thessalonians5:6-8. “So then, let us not be like others, who are asleep, but let us be awake and sober. For those who sleep, sleep at night, and those who get drunk, get drunk at night. But since we belong to the day, let us be sober, putting on faith and love as a breastplate, and the hope of salvation as a helmet.” 18 U.S. Code Chapter 11B - CHEMICAL WEAPONS
The need for an anti-opioid vaccine has only grown in the COVID-19 pandemic. numbers have been increasing since the onset of covid-19 (covert ID - AI) pandemic. According to the American Medical Association, As of 2019 there has been no FDA approved opioid vaccines but now the WHO wants to come out and vaccinate the entire world to prevent the opioid epidemic after following a surge in opioid deaths during the covid Pandemic lock downs according to CELESTE SOLUM https://rumble.com/v4f4c9o-solar-flares-cell-outage-psyop-10-frightening-new-fema-camp-exercises-expos.html The rate of drug overdose deaths involving the synthetic opioid fentanyl more than tripled in the United States from 2016 through 2021, according to a report by the US Centers for Disease Control and Prevention (CDC). A team of addiction experts and vaccine developers across the Boston Children’s research community were recently awarded a $25 million research contract from the NIH’s Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, to develop a vaccine to prevent overdose in opioid users and conduct a clinical trial when it is ready.
The effort is led by the principal investigator team of Ofer Levy MD, PhD and David Dowling, PhD, of Boston Children’s Precision Vaccines Program (PVP). Fentanyl is a synthetic, highly potent opioid that is often added to other drugs like heroin, cocaine, and sometimes even marijuana or they add trank to it , In general narcotic and drug addicts do not get full satisfaction from the drug or a "high" from the relatively slow, diffuse and attenuated effects of orally taken drugs, narcotics and drugs. Instead, they are looking for fast, focused and unrelenting action of a preferably intravenously or "mainline" -injizierten the drug or narcotic to the desired · acute euphoric effect of a "satisfactory" high to reach. Accordingly, addicts sometimes acquire the more readily available oral narcotics, namely analgesics, antitussives, etc., and extract the narcotic substance so that it can be injected. Although people OD by just smoking it after the first or second hit, The abuse of drugs, narcotics and drugs by diverting oral narcotic therapeutic drugs and drugs into illegal channels for injection by addicts has thus become a serious problem in medicine, public health and crime prevention. Opioid overdose is now the leading cause of accidental death in the United States, with record-breaking rates that continue to climb each year right along with inflation they go hand in hand the more drug bought the less money goes back into the economy, There are currently three US Food and Drug Administration–approved drugs to treat OUDs. While these medications consistently demonstrate high efficacy in reducing opioid use and the risk of overdose death. You get a different answer every time you look somewhere, I've heard anywhere from one person OD's on fentanyl every 6 minutes. The goal is to give opioid users a fentanyl-based vaccine that will stimulate their bodies to make antibodies against it. The antibodies would then bind to fentanyl in the blood, thereby blocking it from reaching the brain, where it suppresses respiration. // THE TECHNOLOGY What is it? Opioid vaccines are medical therapies designed to block opioids, such as heroin and fentanyl, from entering the brain or spinal cord, thus preventing addiction and other negative effects. While none are approved for use yet, they could be useful for at-risk individuals, patients in drug recovery programs, or first responders who might accidentally come into contact with deadly opioids that can be absorbed through the skin. This approach offers advantages over some current treatment methods, including requiring minimal medical supervision and no potential for abuse. https://www.gao.gov/assets/gao-19-706sp.pdf
a novel structural formulation of a bi-valent vaccine against morphine/heroin. This vaccine was able to trigger and establish a high titer antibody response to haptenized drug with antibodies displaying equivalent specificities for both morphine and heroin. Such antibodies did not cross-recognize structurally dissimilar opiate medications. Furthermore, the evaluation of the potential therapeutic effectiveness of this vaccine was targeted to relapse prevention using a schedule of heroin delivery in the rat self-administration model. Antibodies against heroin blocked its reinforcing effects in rodents. The type of carrier protein used in this vaccine allows further evaluation of its potential therapeutic value for preventing relapse to heroin addiction in humans. Vaccination may serve as a promising potential remedy to combat accidental overdose and to mitigate the abuse potential of opioids. Previously reported the heroin and fentanyl monovalent vaccines carrying, respectively, a heroin hapten, 6-AmHap, and a fentanyl hapten, para-AmFenHap, conjugated to tetanus toxoid (TT). Herein, described by the mixing of these antigens to formulate a bivalent vaccine adjuvanted with liposomes containing monophosphoryl lipid A (MPLA) adsorbed on aluminum hydroxide. Immunization of mice with the bivalent vaccine resulted in IgG titers of >105 against both haptens. The polyclonal sera bound heroin, 6-acetylmorphine, morphine, and fentanyl with dissociation constants (Kd) of 0.25 to 0.50 nM. Mice were protected from the anti-nociceptive effects of heroin, fentanyl, and heroin +9% (w/w) fentanyl. No cross-reactivity to methadone and buprenorphine was observed in vivo. Naloxone remained efficacious in immunized mice. These results highlighted the potential of combining TT-6-AmHap and TT-para-AmFenHap ( Fentanyl haptens for the preparation of a fentanyl vaccine WO2021146334A1) to yield an efficacious bivalent vaccine Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes. Even though formulations with varying abuse-deterrent technologies have been approved, questions remain about their effectiveness like Suboxone Buprenorphine-wafer for drug substitution therapy US9370512B2 Sublingual and buccal film compositions US11135216B2 or methadone clinics Methadone formulation WO2010066034A1 Researcher Jay Evans directs the UM Center for Translational Medicine, which is working on the vaccines MISSOULA – Researchers at the University of Montana and their partners are nearing human trials for vaccines to prevent fentanyl and heroin drug overdoses.
The vaccines would protect people struggling with drug addiction or those at risk of accidental overdose. According to the National Institutes of Health, more than 106,000 U.S. drug overdose deaths were reported in 2021. Of those, 71,000 can be attributed to synthetic opioids like fentanyl.
Researcher Jay Evans directs the UM Center for Translational Medicine, which is working on the vaccines. He also is co-founder of Inimmune, the corporate partner charged with scaling up the vaccine components for manufacture. Inimmune is based in MonTEC, UM’s Missoula-based business incubator.
“We anticipate testing our vaccines in humans in early 2024,” Dr. Evans said. “The first vaccine will target heroin, followed shortly thereafter with a fentanyl vaccine in Phase I clinical trials. Once we establish safety and early efficacy in these first clinical trials, we hope to advance a combined multivalent vaccine targeting both heroin and fentanyl.” https://www.umt.edu/news/2023/08/082923fent.php Researchers are nearing human trials for vaccines aimed at preventing fentanyl and heroin overdoses. The vaccines could offer a lifeline to those struggling with opioid addiction or at risk of accidental overdose.combining patented adjuvants and cutting-edge research, these vaccines aim to neutralize targeted opioids while sparing medications used for addiction treatment. The first round of human trials is set for early 2024, targeting heroin first, followed by fentanyl. https://neurosciencenews.com/opioid-vaccine-pharmacology-23854/ Fentanyl is an addictive prescription opioid that is over 80 times mora potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous "designer drug' analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, reporting an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross-reactivity for a wide panel of fentanyl analogues, Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug specificity profiling of antibodies derived directly from serum. The newiy developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse.A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models this study tested whether the incorporation of synthetic toll-like receptor (TLR) 4 and TLR7/8 agonists......( Anti-tlr4 antibodies and uses thereof WO2013149111A2 (TLR4 inhibitors for the treatment of human infectious and inflammatory disorders US9072760B2) (Tlr7 agonists WO2019226977A1) ( Cleavable conjugates of tlr7/8 agonist compounds, methods for preparation, and uses thereof US20190151462A1 ) I'm not sure those are the exact ones they're going to use but that's what I found ...as vaccine adjuvants would increase vaccine efficacy against fentanyl challenge, overdose, and self-administration in either rats or Hanford miniature pigs. Formulation of the vaccine with a nucleolipid (patent's that i found on that are 280198979 - EP 1736552 A1 20061227 280198982 - EP 1893773 A2 20080305 US11141378B2 US10166298B2 US20170119904A1 US10166298B2 ) TLR7/8 agonist enhanced its immunogenicity and efficacy in preventing fentanyl-induced respiratory depression, analgesia, bradycardia, and self-administration in either rats or mini-pigs. These studies support the use of TLR7/8 adjuvants in vaccine formulations to improve their clinical efficacy against OUD and potentially other substance use disorders (SUD). https://www.nature.com/articles/s41541-023-00697-9 they tested adjuvants derived from the heat-labile toxin of E. coli including dmLT and LTA1 by intramuscular, sublingual or intranasal delivery. There results show anti-fentanyl serum antibodies and antibody secreting cells in the bone-marrow!! Where have we heard that before Ieee 802.15.??maybe,, or patents US-6754472-B1 - Method and Apparatus for Transmitting Power and Data Using the Human Body US-20090233558-A1 , US-9349280-B2 , US-20090124282-A1 , US-7945064-B2 , US-9949712-B1 , US-8332029-B2 , US-10477330-B2 , US-8433080-B2 , US-10842377-B2 , US-10015604-B2 , US-9882992-B2 , US-20100305437-A1 , US-9736180-B2 , CN-101601210-B , WO-2007028035-A3 , US-20040138723-A1 , US-10678322-B2 , US-9812788-B2 , WO-2004093486-A3 , Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119695/ after vaccination with highest levels observed with an adjuvant (alum, dmLT, or LTA1)......alum patents US5718865A, US3226186A, US1995343A....... DmLT patent WO1999047167A1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060342/ ......... LTA1 patent 2748757 , WO2010078526A1 Vaccine adjuvanted with LTA1 or dmLT elicited the highest levels of anti-fentanyl antibodies, whereas alum achieved highest levels against the carrier protein. Vaccination with sublingual dmLT or intranasal LTA1 provided the most robust blockade of fentanyl-induced analgesia and CNS penetration correlating strongly to anti-FEN IgA.( WO2015120474A1) In conclusion, this study demonstrates dmLT or LTA1 adjuvant as well as mucosal delivery may be attractive strategies for improving the efficacy of vaccines against SUD. https://www.nature.com/articles/s41541-021-00329-0 Purdue Pharma, the maker of OxyContin, Oxycodone formulations uS10660886B2 ..has received a patent designed to treat opioid addiction.
The patent, first reported by The Financial Times, is for a new and faster-acting form of buprenorphine. Buprenorphine controls drug cravings and is often given as a substitute to people hooked on heroin or opioid painkillers such as OxyContin.
Buprenorphine is currently prescribed in tablets or fast-dissolving strips. The patent is for a "wafer" of buprenorphine that would dissolve in just a few seconds The two most commonly used centrally acting opioid receptor antagonists are naloxone and naltrexone. Naltrexone long acting formulations and methods of use US7919499B2 Naloxone comes in intravenous,Stabilized naloxone formulations US5866154A intramuscular, and intranasal formulations and is FDA-approved for use in opioid overdose and the reversal of respiratory depression associated with opioid use Naloxone injection Liquid naloxone spray US10973814B2 is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone injection is also used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is given to newborns to decrease the effects of opiates received by the pregnant mother prior to delivery. Naloxone injection is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Vaccines have treatment potential for methamphetamine (MA) addiction. They tested whether a conjugate vaccine against MA (succinyl-methamphetamine–keyhole limpet hemocyanin carrier protein; SMA-KLH) (US6376508B1 , 5,661,016 ) would generate MA antibodies and alter MA-induced behaviors. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563850/ Researchers say a new vaccine shows promise in blocking fentanyl from entering a person’s brain.They say the vaccine could help reduce overdoses and aid in addiction recovery. Experts, however, point out that the new vaccine has only been tested on rats, so more research is needed on its effectiveness on humans they also note that people who’ve had the vaccine could switch to other opioids. But that's not the case that I found I found a bunch of patents, If you ask me they're just beating around the damn bush putting a Band-Aid on the crap! Why don't they take care of the real problem? Stop it from coming into the country and the other countries like turning fentanyl from a scheduled two drug to a scheduled one drug then they can go after the real problem. Can you believe it's on the same schedule as marijuana ? That's just insane ! Thank God for narcan Who owns the Narcan patent?E mergent BioSolutions Inc. -owned Adapt had sued Teva alongside Opiant Pharmaceuticals Inc., which owns the patents and licenses them to Adapt. Narcan brought in $280 million for Emergent in 2019, according to the company's financial filings.
https://patents.google.com/?q=(Emergent+BioSolutions+Inc+narcan)&oq=Emergent+BioSolutions+Inc+narcan
The FDA approves the overdose-reversing drug Narcan for over-the-counter sales https://www.npr.org/2023/03/29/1166750095/narcan-fda-approval-naloxone-over-the-counter-otc FDA Approves First Over-the-Counter Naloxone Nasal Spray https://www.fda.gov/news-events/press-announcements/fda-approves-first-over-counter-naloxone-nasal-spray , Five years after public health officials first asked for it, Narcan finally hit store shelves this month Walgreens, CVS, Rite Aid, and Walmart are all confirmed to carry the medication starting today and expect to have nationwide availability by Thursday, September 8th.2023 — a potentially pivotal moment in the fight to counter the country’s stubbornly high death toll from heroin, fentanyl and pain pills. Now, anyone can buy the opioid overdose reversal drug without a prescriptio Im not sure that OTC is the answer,” Daniel J. Abdun-Nabi, then Emergent’s top executive, told investors during a November 2018 earnings call. A month later, the company’s then president, Robert Kramer, cautioned “against a rush to an over-the-counter solution for this current crisis,” citing concerns about Narcan awareness and insurance coverage. Naloxone was patented in 1961 by Mozes J. Lewenstein, Jack Fishman, and the company Sankyo. It was approved for opioid use disorder treatment in the United States in 1971. 9,211,253, 9,468,747 and 9,561,117 listed in the U.S. Food and Drug Administration's Orange Book for Narcan® 4 milligram nasal spray. Each of these patents discloses and claims naloxone formulations containing an isotonicity agent. Additional Adapt Pharma also has U.S. Pat. From October 2017 through March 2023, the ROPS distributed more than 450,000 units of naloxone, and TDMHSAS has documented at least 60,000 lives saved Naloxone saves lives. From 1996 to 2014, at least 26,500 opioid overdoses in the United States were reversed by laypersons using naloxone.Safer drug consumption services (SCS) are designated sites where people can use pre-obtained drugs under the safety and support of trained personnel. Over the last 30 years, SCS have been implemented across 100+ sites in 60+ cities in 11 countries around the world. The snowballing death toll has pushed lawmakers in Colorado, New Mexico and Nevada to consider joining New York and Rhode Island in allowing what are often called “safe injection sites.” Also called “overdose prevention centers,” these are places where people can use drugs under the supervision of trained staff who get high as hell OD and get brought back to life ain't no higher high than that...Mar 1, 2023 DRAFT:1 Review Of Those States’ Laws Which Provide Misdemeanor Penalties For Simple Possession of Drugs Other Than Marijuana.NB: Survey Does not Encompass Possession with Intent to Distribute Offense https://www.ajc.state.ak.us/acjc/docs/resources/drugs/misdechrt.pdf The Washington State Legislature passed a compromise drug possession bill during a special session earlier this year called by Gov. Jay Inslee. Senate Bill 5536 sets the penalty for possession of controlled substances as a gross misdemeanor with a maximum confinement time of six months for the first two convictions Drug Possession Laws: 50-State Survey https://www.justia.com/criminal/offenses/drug-crimes/drug-possession-laws-50-state-survey/ Controlled Substance Laws by State 2024 https://worldpopulationreview.com/state-rankings/controlled-substance-laws-by-state Researchers estimate that from 2006 to 2016, the total amount of money spent by Americans on these four drugs fluctuated between $120 billion and $145 billion each year but in all reality it's probably way higher than that You know all the closet smokers The largest amount of federal drug control spending was reported for FY 2022 with some 41 billion U.S. dollars. However, the requested funding for 2023 and 2024 are significantly higher. The biggest bust on record Record fentanyl bust in Nebraska finds enough doses to kill an estimated 26 million people | CNN. The Nebraska State Patrol seized nearly 120 pounds of the drug fentanyl -- enough to kill about 26 million people, according to estimates by the US Drug Enforcement Administration. ................... You ever heard of the Pandora papers? About the American cartel ? Well this will blow your mind ! The Pandora Papers are 11.9 million leaked documents with 2.9 terabytes of data that the International Consortium of Investigative Journalists published beginning on 3 October 2021 Millions of leaked documents and the biggest journalism partnership in history have uncovered financial secrets of 35 current and former world leaders, more than 330 politicians and public officials in 91 countries and territories, and a global lineup of fugitives, con artists and murderers, and drug dealers. https://www.icij.org/investigations/pandora-papers/ https://rumble.com/v4flvr8-mike-gill-and-meghan-walsh-and-fcb-pandora-papers-and-cps-corruption-02-22-.html https://rumble.com/v4a69n0-documentary-the-pandora-papers-how-the-offshore-finance-is-still-flourishin.html https://rumble.com/v43dd9z-michael-jaco-huge-intel-mike-gill-exposes-the-deep-state-pandora-papers-bad.html There is a few vaccines out already let's take a look at their patents It's not all of the patents I found but I know you're bored need something to do
Pretty weird that the FDA says they didn't approve any opioid vaccines as of 2019 but they go all way back to the '80s are they planning something like ooh look we got new ones for the first time like it's some big surprise everybody should do it. Thanks for all that you do to stop this biohack on all that is natural and made in the image of GOD and may Romans 8:31 be our guiding light. 6831